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The sap from the plant can be mildly to very irritating
to mucus membranes and <U>should</U> be kept from children and animals.
As far as being lethally poisonous, it certainly is not.
There are many more common house plants that I would worry about
more than the seasonal poisettia.
There was a commercial in Ohio a number of years ago to prove this point;
as crazy as it may sound, the florists ran a commercial of a
man eating a poinsettia to prove the point.
If they REALLY were that poisonous, just how many of your
Wal-Marts etc. would continue to sell them with absolutely
NO warning, knowing they would be leaving themselves
wide open for a lawsuit for not doing so?